en-MASCULINE - men's supplement, designed by data

Aim

A microbiome-based food supplement for men, built with Digital Twin and AI technology. Your pledge funds our clinical trial and first batch.

Microbiome-based, by design.

Your gut does more than digest food. The trillions of bacteria living there send signals to your brain, your immune system and the glands that produce male hormones. en-MASCULINE is the first men's supplement we have built around that connection.

Most supplement formulas are built on habit: the same ingredients, in the same doses, because that is what has always been sold. We started from gut microbiome data instead, and used our digital twin and AI-powered formulation technology to arrive at one formulation.

It is a food supplement for men, taken once a day as a powder, over a 90-day programme of three monthly jars.

The science behind it

Your gut is home to trillions of bacteria. They don't just help you digest food. They also send signals that reach your brain and the glands that produce male hormones.

Scientists are starting to understand this connection in three ways:

• Hormone processing. Some gut bacteria help your body convert and recycle hormones.
• Inflammation. An imbalanced gut can let bacterial fragments leak into the body, causing low-grade inflammation. This can interfere with the signals your brain uses to regulate hormones.
• Oxidative stress. A balanced gut produces compounds that help protect your cells from damage.

To build en-MASCULINE, we used digital twins: computer models of the gut microbiome, built from population-level data. They let us test thousands of ingredient combinations virtually, before choosing the one that best supports this connection. We are now running a clinical trial to see how it performs in people.

Who we are

We are a UK-based biotech company. Since 2019 we have built Digital Twin and AI models from gut microbiome data and used them to develop food supplements. Each one is a single formulation, based on population-level microbiome patterns rather than on tradition.

Our first product, en-TEAR, is already on the market. We also have en-JOY&FIT in development. Early clinical studies on both have shown encouraging, promising results, and larger controlled trials are now underway to confirm them. Every formulation we release goes through this same process, and en-MASCULINE is next.

The people behind en-MASCULINE:

Ömer Özkan, CEO & Founder 

Ömer Özkan is CEO and Founder of Enbiosis Biotechnology, a UK-based company using Digital Twin and AI-powered microbiome modeling to develop nutraceutical formulations. A believer in food as medicine, he is driven to improve billions of lives. He built and exited a renewable energy venture before founding Enbiosis in 2019.

Assoc. Prof. Özkan Ufuk Nalbantoglu, CTO 

Özkan Ufuk Nalbantoglu is Chief Technical Officer of Enbiosis Biotechnology, where he leads the Digital Twin and AI technology behind the company's formulation engine. An academic specialising in bioinformatics, deep learning and microbiome data analysis, he has over 20 years of experience working on the gut microbiome, has authored numerous peer-reviewed publications in the field, and holds patents in AI-based diagnostics using intestinal microbiome data. He joined Enbiosis to turn years of academic research into real-world formulations.

Dr. Varol Tunalı MD, PhD, Chief Medical Officer

Dr. Varol Tunalı is Chief Medical Officer of Enbiosis Biotechnology, where he designs and oversees the company's clinical studies. A physician specialising in medical parasitology, he has extensive experience leading and publishing randomised controlled trials, and has authored numerous peer-reviewed studies in the field, including a multicentre trial in the American Journal of Gastroenterology. He brings the same clinical rigour to nutraceutical formulation.

What is in it

en-MASCULINE is a food supplement in powder form. Each jar is a one-month supply; one scoop a day. The formulation includes zinc, which contributes to the maintenance of normal testosterone levels in the blood. Every ingredient is a permitted food supplement ingredient in the UK and EU, and the formulation is protected by our own patent filings. It should not be used as a substitute for a varied and balanced diet.

en-MASCULINE is for adult men who:

• want a daily supplement developed from microbiome science rather than trends
• are interested in how gut health connects to the rest of the body
• want to back an early-stage product and follow its clinical trial from the start

Before you take it

en-MASCULINE is a food supplement, not a medicine. It is not intended for anyone under 18. If you have a medical condition or take any medication, please speak to your GP first. Food supplements should not replace a varied, balanced diet and a healthy lifestyle.

What your support funds

• Completing our clinical study: an ethics-approved study run with a university hospital partner.
• Scaling up our first production batch at a certified contract manufacturer.
• Testing, registration and packaging for the UK and EU.

Timeline

• December 2026 — campaign closes
• March 2027 — clinical trial completes
• May 2027 — first production batch
• June 2027 — rewards shipped

Risks and challenges

Clinical studies and first production runs can take longer than planned. If any stage is delayed, we will tell backers straight away through campaign updates and give a revised timeline. We will share study updates with backers as the work progresses.

Funding method

Keep what you raise – this project will receive all pledges made by 30th November 2026 at 10:15am