Time, space, and disorder in the expanding proteom

Time, space, and disorder in the expanding proteom

We are developing new proteomics tools that help to understand life and to improve life of ageing and growing societies.

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Proteomics. 2017 Apr;17(7). doi: 10.1002/pmic.201600399. Epub 2017 Mar 20.

Time, space, and disorder in the expanding proteome universe.

Author information

1
Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.
2
Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.
3
Department of Biochemistry, University of Cambridge, Cambridge, UK.
4
Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA.

Abstract

Proteins are highly dynamic entities. Their myriad functions require specific structures, but proteins' dynamic nature ranges all the way from the local mobility of their amino acid constituents to mobility within and well beyond single cells. A truly comprehensive view of the dynamic structural proteome includes: (i) alternative sequences, (ii) alternative conformations, (iii) alternative interactions with a range of biomolecules, (iv) cellular localizations, (v) alternative behaviors in different cell types. While these aspects have traditionally been explored one protein at a time, we highlight recently emerging global approaches that accelerate comprehensive insights into these facets of the dynamic nature of protein structure. Computational tools that integrate and expand on multiple orthogonal data types promise to enable the transition from a disjointed list of static snapshots to a structurally explicit understanding of the dynamics of cellular mechanisms.